منابع مشابه
Physicochemical properties analysis and dopamine D2 receptor (D2R) docking of zotepine as an atypical antipsychotic antagonist
The main purpose of the present investigation is the study of therapeutically effect of Zotepine in schizophrenia disease treatment. In first step, the molecular structure of the said compound is optimized using density functional theory (DFT) technique by B3LYP functional method at 6-311++G(d,p) level of theory. Then the electronic properties of the title molecule are calculated using frontier...
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BACKGROUND Several of the currently used anticancer drugs may variably affect thyroid function, with impairment ranging from modified total but not free concentration of thyroid hormones to overt thyroid disease. SUMMARY Cytotoxic agents seem to alter thyroid function in a relatively small proportion of adult patients. Anticancer hormone drugs may mainly alter serum levels of thyroid hormone-...
متن کاملAn Unintended Consequence
n engl j med 358;14 www.nejm.org april 3, 2008 1496 From the Departments of Medicine (N.S., C.L.A.) and Surgery (D.J.), University of Wisconsin School of Medicine, Madison; and the Department of Internal Medicine, University of Michigan Medical School (D.R.K., S.S.), and the Ann Arbor Veterans Affairs Health Services Research and Development Center of Excellence (S.S.) — both in Ann Arbor. Addr...
متن کاملCannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.
A high dose of delta9-tetrahydrocannabinol, the main Cannabis sativa (cannabis) component, induces anxiety and psychotic-like symptoms in healthy volunteers. These effects of delta9-tetrahydrocannabinol are significantly reduced by cannabidiol (CBD), a cannabis constituent which is devoid of the typical effects of the plant. This observation led us to suspect that CBD could have anxiolytic and/...
متن کاملRepurposing the antipsychotic trifluoperazine as an antimetastasis agent.
Because cancer cell invasion is a critical determinant of metastasis, targeting invasion is a viable approach to prevent metastasis. Utilizing a novel three-dimensional high-throughput invasion assay, we screened a National Cancer Institute compound library and discovered compounds demonstrating inhibitory effects on cancer cell invasion. One hit, trifluoperazine, suppresses invasion of human c...
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ژورنال
عنوان ژورنال: Canadian Pharmacists Journal / Revue des Pharmaciens du Canada
سال: 2014
ISSN: 1715-1635,1913-701X
DOI: 10.1177/1715163514521969